zoom.sc_tool.compute_gss

zoom.sc_tool.compute_gss(adata: anndata.AnnData, n_jobs: int) → anndata.AnnData[source]

Calculates the gene expression rank for each cell.

Parameters:

  • adata (ad.AnnData) – The AnnData object containing expression data.

  • gss_limit (float) – Allowed maximum GSS value to avoid over-representation.

  • n_jobs (int) – Number of cores for parallel computation.

Returns:

adata – The AnnData object with a new layer adata.layers[‘gss’] containing the gene specificity scores.

Return type:

ad.AnnData

References

Song, L., Chen, W., Hou, J., Guo, M. & Yang, J. Spatially resolved mapping of cells associated with human complex traits. Nature 641 932-941 (2025).